NSI-189 is an antidepressant and neurogenic chemical that may be able to improve cognitive function, treat traumatic brain injury, Alzheimer's Disease (AD), Post-Traumatic Stress Disorder (PTSD), and stroke, and prevent cognitive and memory decline in aging.
4 BENEFITS OF NERO
1. May Improve Cognition
NSI-189 may improve cognition. It can improve Long-Term Potentiation (LTP). For example, in genetic altered mice to have Angelman Syndrome, NSI-189 taken orally could return LTP to these mice. NSI-189 may also protect against radiation-induced memory impairment. NSI-189 can also increase neurotrophic factors such as Stem Cell Factor (SCF), Brain-Derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and Glial-Derived Neurotrophic Factor (GDNF).
2. May Improve Depression
Destruction of the hippocampus is a common pathology in Major Depressive Disorder (MDD). NSI-189 may effectively treat MDD as well as other psychiatric disorders by increasing neurogenesis (growth) in the hippocampus. Although in 2017, it was announced that a phase II clinical trial with 220 patients failed to meet its primary effectiveness endpoint in MDD.
3. May Help With Stroke
NSI-189 may improve motor function and hippocampal deficits seen in oxygen-deficit (hypoxia) stroke. One reason for this is by NSI-189's ability to significantly increase the neurotrophic factors VEGF, BDNF, GDNF, and SCF. For example, in mice that were given a stroke, NSI-189 treatment continually helped improve deficits in these mice, even after cessation of the drug.
4. May Help With Diabetes
NSI-189 may be able to protect nerves from toxicity in diabetes. It may help with nerve pain and neuropathy in diabetes.!